In this paper the response of a number of structural models subjected to different loading conditions is analysed with the codes PLAXIS 3D and SAP2000. The goal of such a comparison is the assessment of the structural elements performance in PLAXIS 3D as compared to that obtained by the well-known SAP2000, a widely used code for structural analysis. An overall good match was obtained, as such highlighting the possibility to use the code PLAXIS 3D to perform both structural and geotechnical calculations in soil-structure interaction problems.