Answer: 

AutoPIPE Vessel is designed to perform Tubesheet calculations for various load cases, taking into account default scenarios with different pressure and temperature values. Users have the flexibility to add or remove load cases and modify the pressure and temperature values as needed.

Below is a snapshot showing how you can update these details:

To enable / disable Differential Pressure Design, double left mouse click on the respective tubesheet in the component column to the left. After the dialog opens, choose Supplemental Design Data tab> Design Conditions area> Enable / Disable option for "Use Differential Pressure Design" option.